The intestinal epithelium tuft cells: specification and function
نویسندگان
چکیده
منابع مشابه
DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium.
Cancer. The authors thank Drs D. Fisher and A. Camasses for helpful discussion.
متن کاملDistinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium
The unique morphology of tuft cells was first revealed by electron microscopy analyses in several endoderm-derived epithelia. Here, we explore the relationship of these cells with the other cell types of the intestinal epithelium and describe the first marker signature allowing their unambiguous identification. We demonstrate that although mature tuft cells express DCLK1, a putative marker of q...
متن کاملDclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal
To date, no discrete genetic signature has been defined for isolated Dclk1+ tuft cells within the small intestine. Furthermore, recent reports on the functional significance of Dclk1+ cells in the small intestine have been inconsistent. These cells have been proposed to be fully differentiated cells, reserve stem cells, and tumor stem cells. In order to elucidate the potential function of Dclk1...
متن کاملLong-lived intestinal tuft cells serve as colon cancer-initiating cells.
Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has been proposed to identify quiescent and tumor growth-sustaining stem cells. DCLK1⁺ tuft cells are increased in inflammation-induced carcinogenesis; however, the role of these cells within the gastrointestinal epithelium and their potential as cancer-initiating cells are poorly understood. Here, using a BA...
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The microanatomy of the intestinal epithelium in the Chinese soft-shelled turtle (CST) was studied by light and transmission electron microscopy (TEM). The small intestinal epithelium (SIE) was single layered or pseudostratified. The enterocytes contained mitochondria or mitochondria and lipid droplets. The enterocytes were arranged tightly in the apical parts of epithelium and connected by des...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2012
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-012-0984-7